Chemical Name: (5R,9R,11E)-5-Amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridine-2(1H)-one. Alternate Names: (-)-Huperzine A, (-)-Selagine
Acetylcholinesterase inhibitor
Molecular Weight:
242.32
Purity:
>98% by HPLC NMR (Conforms)
Form:
White to off-white solid
CAS Number:
[102518-79-6]
Formula:
C15H18N2O
Application Notes:
Huperzine A (102518-79-6) is a nootropic alkaloid from the club moss Huperzia serrata that reversibly inhibits acetylcholinesterase (AChE, preferentially the tetrameric form, Ki = 7 nM)1, and antagonizes NMDA receptors (IC50 rat cerebral cortex = 126 µM)2. It is thought to have cognitive-enhancing properties, including amelioration of Alzheimers disease.3,4 Recently, it has also been shown to rescue ovarian function in rats5 as well as display analgesic activity in a rat spinal cord compression model6.
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