Chemical Name: O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
O-GlcNAcase inhibitor
Molecular Weight:
353.33
Purity:
98% by TLC NMR (Conforms)
Form:
White solid
CAS Number:
[132489-69-1]
Formula:
C15H19N3O7
Application Notes:
O-GlcNAcase (O-GlcNAc-beta-N-acetylglucosaminidase) and beta-hexosaminidase inhibitor (Kii=46 and 36 nM, respectively). A widely used tool for increasing cellular levels of O-GlcNAc.2 Protects cardiac function after trauma-hemorrhage which is mediated by increased protein O-GlcNAc levels.3 Induces insulin resistance in rat skeletal muscle.4
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