Echinomycin, CAS [[512-64-1]]

Product Overview

• Article Name: Echinomycin, CAS [[512-64-1]]
• Biozol Catalog Number: FBM-10-2424
• Supplier Catalog Number: 10-2424
• Alternative Catalog Number: FBM-10-2424-1MG,FBM-10-2424-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Quinomycin A, NSC-13502

Product Description

HIF1alpha inhibitor

Product Properties

• Molecular Weight: 1101.26
• Purity: >97% by HPLC NMR (Conforms)
• Form: White to beige solid
• CAS Number: [512-64-1]
• Formula: C51H64N12O12S2

Application Notes

• Application Notes: Echinomycin is a potent and selective hypoxia inducible factor 1alpha (HIF-1alpha) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1alpha.1 Protects mice against relapsed acute myeloid leukemia with no effect on hematopoietic stem cells.2 Selectively eliminates cancer stem cells in mouse lymphoma and human AML xenogeneic models.3 A very useful tool for probing genes regulated by HIF1alpha.4