Chemical Name: 4-[4-(methylulfonyl)phenyl]-3-phenyl-2(5H)-furanone. Alternate Names: MK-966
Selective COX-2 inhibitor
Molecular Weight:
314.36
Purity:
98% by HPLC, NMR (conforms)
Form:
Off-white solid
CAS Number:
[162011-90-7]
Formula:
C17H14O4S
Application Notes:
Potent and selective COX-2 inhibitor with 1000-fold selectivity over COX-1, IC50=26 nm vs >50 µM1. Potent nonsteroidal anti-inflammatory agent1. Clinically useful NSAID which was withdrawn from use due to cardiovascular side effects3.
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