Chemical Name: N-formyl-L-leucine (1S)-10[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester. Alternate Names: Ro18-0647, (-)-Tetrahydrolipstatin
DAG Lipase-alpha inhibitor
Molecular Weight:
495.75
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[96829-58-2]
Formula:
C29H53NO5
Application Notes:
A lipase inhibitor which blocks the biosynthesis of 2-AG by inhibition of DAG lipase-alpha1. Inhibits pancreatic lipase and other lipases but not PLA22. Inhibits fatty acid synthase and displays antitumor activity3. Prevents fat absorption in the gut and is a clinically useful antiobesity agent4.
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