Chemical Name: 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Monoamine transporter inhibitor
Molecular Weight:
276.20
Purity:
>98% by HPLC, NMR (Conforms)
Form:
White solid
CAS Number:
[31677-93-7]
Formula:
C13H18ClNOHCl
Application Notes:
Clinically useful antidepressant that inhibits monoamine transporters DAT, NET, and SERT (Kis for dopamine uptake = 2.8, 1.4, 45 µM).1 Also acts as a noncompetitive antagonist at nicotinic acetylcholine receptors (AChRs).2 At higher concentrations (50 µM), stimulates pro-inflammatory cytokines and TLR2/TLR4 and JAK2/STAT3 in human peripheral blood mononuclear cells (PBMCs).3
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