Chemical Name: 1,2,4,5-Benzenetetramine tetrahydrochloride. Alternate Names: Y15
FAK inhibitor
Molecular Weight:
284.02
Purity:
98% by TLC, NMR (Conforms)
Form:
Grey solid
CAS Number:
[4506-66-5]
Formula:
C6H10N4 4HCl
Application Notes:
Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 µM), promotes cell detachment and inhibits cell adhesion in vitro. Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo. Induces regression of pancreatic tumors2 and glioblastoma3. Displays antiangiogenic activity4.
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