Chemical Name: (15R)-17-Demethoxy-15 methoxy-11-O-methyl-geldanamycin
Src inhibitor
Molecular Weight:
574.68
Purity:
98% by HPLC NMR (Conforms)
Form:
Yellow lyophilized solid
CAS Number:
[70563-58-5]
Formula:
C30H42N2O9
Application Notes:
Ansamycin antibiotic. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB21,2. Reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity1. Inhibits angiogenesis in a rat retinopathy model3.
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