Chemical Name: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate,. Alternate Names: ICI-204636
Atypical antipsychotic agent
Molecular Weight:
441.54
Purity:
>98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[111974-72-2]
Formula:
C21H25N3O2 S0.5C4H4O4
Application Notes:
Atypical antipsychotic agent. Antagonist at serotonin (5-HT2) and dopamine (D2) receptors, IC50s=148 and 329 nM respectively.2 Reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation in a rat model.3 Efficacious as a monotherapy in the treatment of posttraumatic stress disorder.4
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