Chemical Name: Produced from Streptomyces sp. Alternate Names: Antimycin A Complex
Mitochondrial complex III inhibitor
Molecular Weight:
548.63
Purity:
>97% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[1397-94-0]
Formula:
C28H40N2O9
Application Notes:
Mitochondrial electron transport inhibitor at complex III. Induces apoptosis in various cell lines.1 Antimycin A may be used to generate cellular models of degenerative disorders by blocking the mitochondrial electron transport chain, disrupting energy metabolism, and elevating ROS levels.2-4 Induces canonical PINK1-Parkin-dependent mitophagy in Parkin overexpressing cells upon cotreatment with oligomycin.5
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