Triptolide, CAS [[38748-32-2]]

Product Overview

• Article Name: Triptolide, CAS [[38748-32-2]]
• Biozol Catalog Number: FBM-10-2631
• Supplier Catalog Number: 10-2631
• Alternative Catalog Number: FBM-10-2631-1MG, FBM-10-2631-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one. Alternate Names: PG490

Product Description

Immunosupressant

Product Properties

• Molecular Weight: 360.40
• Purity: 98% by HPLC, NMR (Conforms)
• Form: Tan solid
• CAS Number: [38748-32-2]
• Formula: C20H24O6

Application Notes

• Application Notes: Possesses potent immunosuppressive and anti-inflammatory activity. Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1 Blocks transactivation of NFkappaB.2 Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and synergizes with other anticancer agents.3 Inhibits the inflammatory response and remarkably decreases production of TNF-alpha, IL-1beta and IL-6 in a rat model of rheumatoid arthritis.4