A polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma1. Displays selective toxicity for cancer stem cells1. Induces rapid mitochondrial hyperpolarization2. Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway3. Reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity4. Kills cancer stem cells by sequestering iron.5
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