Obatoclax, CAS [[803712-79-0]]

Product Overview

• Article Name: Obatoclax, CAS [[803712-79-0]]
• Biozol Catalog Number: FBM-10-2660
• Supplier Catalog Number: 10-2660
• Alternative Catalog Number: FBM-10-2660-5MG, FBM-10-2660-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate. Alternate Names: GX15-070

Product Description

BCL-2 antagonist, Induces apoptosis

Product Properties

• Molecular Weight: 413.50
• Purity: 98% by TLC
• Form: Purple solid
• CAS Number: [803712-79-0]
• Formula: C20H19N3O CH3SO3H

Application Notes

• Application Notes: A novel Bcl-2 homology domain-3 (BH3) mimetic1. Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 µM) and induces apoptosis in primary AML cells (IC50= 3.6 µM)2. Synergizes with other agents such as chloroquine3 and cytarabine4 in cytotoxicity against a variety of cancer cells.