Probucol, CAS [[23288-49-5]]

Product Overview

• Article Name: Probucol, CAS [[23288-49-5]]
• Biozol Catalog Number: FBM-10-2679
• Supplier Catalog Number: 10-2679
• Alternative Catalog Number: FBM-10-2679-1G, FBM-10-2679-10G
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4,4-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-phenol. Alternate Names: DH-581

Product Description

Antioxidant hypercholesterolemic agent

Product Properties

• Molecular Weight: 516.84
• Purity: 98% by HPLC / TLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [23288-49-5]
• Formula: C31H48O2S2

Application Notes

• Application Notes: Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6