Chemical Name: 3-Methyl-3H-purin-6-amine. Alternate Names: 3-MA
Autophagosome inhibitor
Molecular Weight:
149.15
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[5142-23-4]
Formula:
C6H7N5
Application Notes:
Inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and hydroxyphenazine-induced toxicity3. Enhances celastrol-induced apoptosis in human pancreatic cancer cells4.
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