A selective serotonin reuptake inhibitor (SSRI) with high selectivity for the serotonin transporter (Kd=0.81 nM) over the norepinephrine (Kd=240 nM) and dopamine (Kd=3.6 M) transporters.1 A clinically useful antidepressive agent.2 Has shown some potential in autism spectrum disorders.3 Attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage.4 Orally active and active in vivo. Increases proliferation of neuronal precursors derived from human embryonic stem cells, inducing differentiation and strongly enhancing neuronal characteristics.5
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