8-pCPT-2-O-Me-cAMP-AM, CAS [[1152197-23-3]]

Product Overview

• Article Name: 8-pCPT-2-O-Me-cAMP-AM, CAS [[1152197-23-3]]
• Biozol Catalog Number: FBM-10-2736
• Supplier Catalog Number: 10-2736
• Alternative Catalog Number: FBM-10-2736-100UG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 8-(4-Chlorophenylthio)-2-O-methyladenosine-3,5-cyclic monophosphate, acetoxymethyl ester

Product Description

Epac activator

Product Properties

• Molecular Weight: 557.91
• Purity: 97% by HPLC
• Form: solid
• CAS Number: [1152197-23-3]
• Formula: C20H21ClN5O8PS

Application Notes

• Application Notes: A potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator1. Induces RAP1 activation and insulin secretion in pancreatic beta cell lines2-5. Induces vascular relaxation in rat mesenteric artery6. The acetoxymethyl ester confers increased cell-permeability and is cleaved by endogenous esterases to yield the active compound, 8-pCPT-2-O-Me-cAMP. Addition to cell cultures should be done in serum-free media as esterases in serum will cleave the acetoxymethyl ester and reduce cell permeability.