Chemical Name: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride. Alternate Names: OKY-046
Thromboxane synthase inhibitor
Molecular Weight:
264.71
Purity:
98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[78712-43-3]
Formula:
C13H12N2O2 HCl
Application Notes:
Potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM)1. Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM)1. Inhibits platelet aggregation2 in vitro and arachidonate-induced arterial contraction in vivo. Protects against arachidonate-induced sudden death in the rabbit3. Alleviates liver injury induced by acetaminophen overdose in mice4.
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