Riluzole, CAS [[1744-22-5]]

Product Overview

• Article Name: Riluzole, CAS [[1744-22-5]]
• Biozol Catalog Number: FBM-10-2815
• Supplier Catalog Number: 10-2815
• Alternative Catalog Number: FBM-10-2815-20MG, FBM-10-2815-100MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-Amino-6-(trifluoromethoxy)benzothiazole

Product Description

Sodium channel blocker / Neuroprotective

Product Properties

• Molecular Weight: 234.20
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [1744-22-5]
• Formula: C8H5F3N2OS

Application Notes

• Application Notes: Riluzole is a clinically useful drug for the treatment of amyotrophic lateral sclerosis (ALS).1 Riluzole inhibits glutamate release via inactivation of voltage-dependent ion channels, effects expression and signal transduction of glutamate receptors, and facilitates glutamate uptake.2,3,4 It has also been investigated as a treatment for depression and anxiety.5 Riluzole induced apoptosis in mGluR1-expressing melanoma cells6, inhibited cell proliferation in a U87MG glioblastoma model via blockage of glutamate release7, and inhibited the growth of brain tumor stem-like cells via downregulation of GLUT3.