Ethacrynic acid, CAS [[58-54-8]]

Product Overview

• Article Name: Ethacrynic acid, CAS [[58-54-8]]
• Biozol Catalog Number: FBM-10-2826
• Supplier Catalog Number: 10-2826
• Alternative Catalog Number: FBM-10-2826-1G,FBM-10-2826-5G
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2,3-Dichloro-4-(2-methylenebutanoyl)phenoxyacetic acid. Alternate Names: MK-595, NSC-85791

Product Description

Glutathione transferase inhibitor

Product Properties

• Molecular Weight: 303.14
• Purity: >99% by HPLC, NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [58-54-8]
• Formula: C13H12Cl2O4

Application Notes

• Application Notes: Ethacrynic acid (58-54-8) was found to be an inhibitor of glutathione transferase P1-1 (GST P1-1) in a screen of FDA-approved drugs. It inhibits both GST P1-1 and A3-1, IC50s=4.9 and 0.4 µM respectively and apparently acts as an allosteric inhibitor.1 It forms conjugates with glutathione which also inhibit GST competitively.2 Ethacrynic acid is cytotoxic to a number of cancer cells3 and synergizes with anticancer agents like afatinib4. It is a clinically useful diuretic agent.5