Purvalanol A, CAS [[212844-53-6]]

Product Overview

• Article Name: Purvalanol A, CAS [[212844-53-6]]
• Biozol Catalog Number: FBM-10-2868
• Supplier Catalog Number: 10-2868
• Alternative Catalog Number: FBM-10-2868-5MG, FBM-10-2868-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol. Alternate Names: NG-60

Product Description

CDK inhibitor

Product Properties

• Molecular Weight: 388.89
• Purity: 98% by HPLC, NMR (Conforms)
• Form: Pale green solid
• CAS Number: [212844-53-6]
• Formula: C19H25ClN6O

Application Notes

• Application Notes: Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests synchronized cells in G1 and G2 phase.2 Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3 Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4 In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5 Cell permeable.