A novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist1. It drives IL-22 production by stimulating the differentiation of human and mouse T cells producing IL-221. Induces apoptosis in thymocytes2. Activates type 4 metabotropic glutamate receptors3. Counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Displays neuroprotective activity3.
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