Chemical Name: (S)-1-[N-(3-Hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile. Alternate Names: LAF237
DPP4 inhibitor
Molecular Weight:
303.40
Purity:
98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[274901-16-5]
Formula:
C17H25N3O2
Application Notes:
A potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1)1. Delaying the degradation of GLP-1 extends the action of insulin and suppressing the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia)2. Clinically useful antidiabetic agent. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model3. Displays protective effects on beta-cells by inhibition of ER stress in a mouse model4.
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