A reagent for selective reduction of disulfides in aqueous solutions1-3 with distinct advantages over DTT which are application specific3. For example, spin labels are more stable with TCEP than DTT, Ni2+ (leached from affinity columns) causes rapid oxidation of DTT with no effect on TCEP and for long term storage of proteins TCEP is more stable than DTT with no metal chelator (EGTA) present but DTT is more stable in the presence of metal chelators.3
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