Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt. Alternate Names: CRID3, CP-456773 sodium salt
NLRP3 inflammasome inhibitor
Molecular Weight:
426.46
Purity:
98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[210826-40-7]
Formula:
C20H23N2O5S Na
Application Notes:
MCC950 was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-11. Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes2. Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1beta (IL-1beta) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)3. Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome4. A valuable new tool for exploring the pathophysiology of NLRP3.
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