CX-5461, CAS [[1138549-36-6]]

Product Overview

• Article Name: CX-5461, CAS [[1138549-36-6]]
• Biozol Catalog Number: FBM-10-2998
• Supplier Catalog Number: 10-2998
• Alternative Catalog Number: FBM-10-2998-5MG, FBM-10-2998-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo [3,2-a][1,8]naphthyridine-6-carboxamide

Product Description

RNA polymerase I inhibitor

Product Properties

• Molecular Weight: 513.62
• Purity: >98% by HPLC, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1138549-36-6]
• Formula: C27H27N7O2S

Application Notes

• Application Notes: CX-5461 (1138549-36-6) is a first-in-class selective RNA polymerase I inhibitor, suppressing Pol I transcription in MV 4,11 myelomonocytic leukemia cells and SR immunoblastic lymphoma cells with EC50 values of 95 and 135 nM respectively and demonstrating 200-fold selectivity over Pol II.1,2 Activates the DNA damage response.3 It induces a rapid accumulation of cytosolic DNA which results in upregulation of STING.4 Acts as a potent immunosuppressant inhibiting T cell-mediated alloimmunity and representing a novel class of immunosuppressant.5