Torin 1, CAS [[1222998-36-8]]

Product Overview

• Article Name: Torin 1, CAS [[1222998-36-8]]
• Biozol Catalog Number: FBM-10-3013
• Supplier Catalog Number: 10-3013
• Alternative Catalog Number: FBM-10-3013-5MG, FBM-10-3013-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one

Product Description

mTOR inhibitor

Product Properties

• Molecular Weight: 607.62
• Purity: 98% by HPLC, NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [1222998-36-8]
• Formula: C35H28F3N5O2

Application Notes

• Application Notes: Potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively.1,2 Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg).2 Induces autophagy.3 Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models.4 Downregulates NGF expression in RSC96 cells.5