ARV-110, CAS [[2222112-77-6]]

Product Overview

• Article Name: ARV-110, CAS [[2222112-77-6]]
• Biozol Catalog Number: FBM-10-3016
• Supplier Catalog Number: 10-3016
• Alternative Catalog Number: FBM-10-3016-5MG, FBM-10-3016-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide. Alternate Names: Bavdegalutamide

Product Description

Androgen receptor degrader

Product Properties

• Molecular Weight: 812.30
• Purity: 98% by HPLC NMR (Conforms)
• Form: Pale yellow solid
• CAS Number: [2222112-77-6]
• Formula: C41H43ClFN9O6

Application Notes

• Application Notes: ARV-110 is a CRBN-based PROTAC protein degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the androgen receptor (AR). It selectively degrades wild-type AR and most clinically relevant mutants with low nM potency.1 ARV-110 is the first PROTAC to enter the clinic.2 Analytical methods suitable for pharmacokinetic studies have been developed.3