Chemical Name: (3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
TAK1 inhibitor
Molecular Weight:
362.38
Purity:
>98% by HPLC NMR (Conforms)
Form:
White to off-white solid
CAS Number:
[253863-19-3]
Formula:
C19H22O7
Application Notes:
Potent and selective inhibitor of TAK1 (mitogen activated protein kinase kinase kinase) IC50 = 8 nM.1 Selective over MEKK1 and MEKK4. Blocks IL-1-induced activation of TAK1 in cell culture.1 Blocks the production of pro-inflammatory cytokines and displays anti-inflammatory activity in various models.2-4
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