SPHINX is a potent inhibitor of SRPK1 (Serine/arginine-rich protein kinase 1), IC50 = 0.88 uM which is selective over SRPK2 (IC50 > 10 uM).1 SRPK1 is a splice factor kinase which drives the activity of splice factors such as SRSF1. Inhibition of SRPK1 by SPHINX in K561 leukemia and PC3 prostate cancer cell lines reduced cell proliferation, invasion and migration.2 In combination with azacitidine, SPHINX reduced viability and increased apoptosis in the acute myeloid leukemia cell line Kasumi-1.3
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