Chemical Name: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide
Arylhydrocarbon receptor antagonist
Molecular Weight:
333.39
Purity:
98% by TLC, NMR (Conforms)
Form:
Orange solid
CAS Number:
[301326-22-7]
Formula:
C19H19N5O
Application Notes:
Arylhydrocarbon (AhR) receptor antagonist, IC50=30 nM.1 Blocks endogenous AhR agonist-induced differentiation of Th17 cells.2 Promotes expansion of human hematopoietic stem cells.3 Mitigates cytokine-mediated inflammatory signaling in human fibroblast-like synoviocytes.4 An important tool for probing the involvement of AhR in the toxicity of various environmental toxins such as TCDD and other dioxins.5
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