Reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays neurotrophic effects.3 Produces antidepressant-like effects in mice.4 Blocks the spontaneous down-regulation of Nav1.8 sodium channels expressed in Xenopus oocytes.5
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