ABT-263, CAS [[923564-51-6]]

Product Overview

• Article Name: ABT-263, CAS [[923564-51-6]]
• Biozol Catalog Number: FBM-10-3141
• Supplier Catalog Number: 10-3141
• Alternative Catalog Number: FBM-10-3141-5MG, FBM-10-3141-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)- 3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]-phenyl]sulfonyl]-benzamide. Alternate Names: Navitoclax

Product Description

Bcl-2 family inhibitor, Senolytic agent

Product Properties

• Molecular Weight: 974.6
• Purity: 98% by HPLC (NMR Conforms)
• Form: White solid
• CAS Number: [923564-51-6]
• Formula: C47H55ClF3N5O6S3

Application Notes

• Application Notes: Potent and selective Bcl-2 family inhibitor / BH3 domain mimetic which binds to Bcl-2, Bcl-xL and Bcl-w (Ki<1 nM). A useful tool compound which has shown interesting results in various cancer clinical trials2. Synergizes with deoxyglucose and other agents, inducing apoptosis in cancer cells in a xenograft mouse model3. A novel senolytic agent, inducing apoptosis preferentially in senescent cells in a cell type-restricted manner4.