Cabozantinib, CAS [[849217-68-1]]

Product Overview

• Article Name: Cabozantinib, CAS [[849217-68-1]]
• Biozol Catalog Number: FBM-10-3231
• Supplier Catalog Number: 10-3231
• Alternative Catalog Number: FBM-10-3231-5MG, FBM-10-3231-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide. Alternate Names: XL-184, BMS-907351,

Product Description

Met and VEGFR2 inhibitor

Product Properties

• Molecular Weight: 501.51
• Purity: 98% by HPLC, NMR (Conforms)
• Form: White solid
• CAS Number: [849217-68-1]
• Formula: C28H24FN3O5

Application Notes

• Application Notes: Novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM respectively. In cellular assays it inhibits the following kinases: MET, VEGF2, KIT, FLT3 and AXL, IC50=7.8, 1.9, 5.0, 7.5 and 42 µM respectively.1 Eliminated approximately 80% of vasculature in spontaneous pancreatic islet tumors over 7 days in a mouse model.2 Clinically useful anticancer agent.3