Chemical Name: 5-[[5-Bromo-2-[(2-bromophrnyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone. Alternate Names: PRL-3 inhibitor I
PRL-3 phosphatase inhibitor
Molecular Weight:
485.21
Purity:
98% by TLC, NMr (Conforms)
Form:
Yellow solid
CAS Number:
[893449-38-2]
Formula:
C17H11Br2NO2S2
Application Notes:
Potent inhibitor of phosphatase of regenerating liver-3 (PRL-3), IC50=0.9 µM.1 Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.2 Sensitizes PRL-3-expressing cancer cells to chemotherapeutics.3 Inhibits dephosphorylation of tyrosine-783 of integrin beta1 in BGC823 and SW480 cells.4
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