Chemical Name: Oxo-8,9-dithiabicyclo[5.2.0]non-1,4,6-triene-2-carboxylic acid
Cytotoxic disulfide antibiotic
Molecular Weight:
212.25
Purity:
98% by HPLC, NMR (Conforms)
Form:
Orange
CAS Number:
[750590-18-2]
Formula:
C8H4O3S2
Application Notes:
Displays potent broad-spectrum anticancer activity.1 Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress).2 A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.3
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