Rucaparib phosphate, CAS [[459868-92-9]]

Product Overview

• Article Name: Rucaparib phosphate, CAS [[459868-92-9]]
• Biozol Catalog Number: FBM-10-3321
• Supplier Catalog Number: 10-3321
• Alternative Catalog Number: FBM-10-3321-5MG, FBM-10-3321-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one. Alternate Names: AG-14699, PF01367338

Product Description

PARP1 inhibitor

Product Properties

• Molecular Weight: 421.36
• Purity: 98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [459868-92-9]
• Formula: C19H18FN3O H3PO4

Application Notes

• Application Notes: Rucaparib is a potent (Ki<5 nM) PARP1 inhibitor.1 Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2 Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines.3 Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel3 and temozolamide.4 Ameliorates the cardiotoxicity of doxorubicin.5 Recently approved for human use by the FDA.