Chemical Name: N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
LXR agonist
Molecular Weight:
481.33
Purity:
>98% by TLC NMR (Conforms)
Form:
White to off-white solid
CAS Number:
[293754-55-9]
Formula:
C17H12F9NO3S
Application Notes:
Potent high affinity liver X receptor (LXRalpha and beta) agonist, EC50~50 nM.1 Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in inhibition of cholesterol absorption. Inverse agonist at CAR.2 T0901317 was also shown to be an FXR agonist at lower potency than LXR thus appropriate controls must be employed when using this compound as a pharmacological tool.3 Decreases amyloid beta production in a mouse model of Alzheimers disease.4 Inhibits cellular senescence in endothelial cells.5
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