RITA, CAS [[213261-59-7]]

Product Overview

• Article Name: RITA, CAS [[213261-59-7]]
• Biozol Catalog Number: FBM-10-3385
• Supplier Catalog Number: 10-3385
• Alternative Catalog Number: FBM-10-3385-5MG, FBM-10-3385-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 5,5-(2,5-Furandiyl)bis-2-thiophenemethanol. Alternate Names: NSC 652287

Product Description

p53 activator

Product Properties

• Molecular Weight: 292.37
• Purity: 98% by TLC NMr (Conforms)
• Form: Yellow solid
• CAS Number: [213261-59-7]
• Formula: C14H12O3S2

Application Notes

• Application Notes: RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 (human ortholog of MDM2, Mouse Double-Minute clone 2), and targeting it for proteasomal degradation.1 It also weakly (computed Kd = 22 µM) binds HDM2 in the cleft that contacts the p53 transactivation domain.2 Its restoration of mutant p53 function depends on eIF2alpha phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK/SAPK/p38, protein translation) pathways.3-5 Induces senescence in head and neck cancer cells.6