GSK126, CAS [[1346574-57-9]]

Product Overview

• Article Name: GSK126, CAS [[1346574-57-9]]
• Biozol Catalog Number: FBM-10-3394
• Supplier Catalog Number: 10-3394
• Alternative Catalog Number: FBM-10-3394-5MG, FBM-10-3394-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide. Alternate Names: GSK-2816126

Product Description

EZH2 methyltransferase inhibitor

Product Properties

• Molecular Weight: 526.69
• Purity: 98% by HPLC/TLC, NMR (Conforms)
• Form: Cream colored solid
• CAS Number: [1346574-57-9]
• Formula: C31H38N6O2

Application Notes

• Application Notes: Potent, selective, S-adenosyl-methionine-competitive inhibitor of EZH2 methyltransferase, Ki=0.5-3 nM, >150-fold selective for EZH2 over EZH1 and >1000-fold selective over 20 methyltransferases.1 Decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. GSK-126 inhibits proliferation of diffuse large B-cell lymphoma (DLBCL) cell lines as well as DLBCL xenografts in mice.1 Rescues exhausted CD8+ T cells in HCV infection.2 Facilitates the transition of embryonic stem cells to feeder-free extended pluripotent stem cells in combination with a cocktail of other agents.3 Displays neuroprotective effects in ischemic brain injury in a rodent model.4