Chemical Name: (5a,10a)-9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione, mesylate
Vascular serotonin receptor agonist
Molecular Weight:
679.79
Purity:
>98% by HPLC, NMR (Conforms)
Form:
Off-white solid
CAS Number:
[6190-39-2]
Formula:
C33H37N5O5 CH3SO3H
Application Notes:
Dihydroergotamine mesylate (6190-39-2) is a full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively1 and also at 5HT1A and 5HT1F receptors2. One of the oldest agents for treatment of migraine.3 Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.4
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