B02, CAS [[1290541-46-6]]

Product Overview

• Article Name: B02, CAS [[1290541-46-6]]
• Biozol Catalog Number: FBM-10-3425
• Supplier Catalog Number: 10-3425
• Alternative Catalog Number: FBM-10-3425-5MG, FBM-10-3425-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

Product Description

RAD51 inhibitor

Product Properties

• Molecular Weight: 339.40
• Purity: >98% by HPLC NMR (Conforms)
• Form: Pale yellow solid
• CAS Number: [1290541-46-6]
• Formula: C22H17N3O

Application Notes

• Application Notes: RAD51 is a key protein involved in homologous recombination that plays a critical role in the repair of DNA double-strand breaks (DSB) and interstrand cross-links (ICL).1 B02 (1290541-46-6) was identified in a high-throughput screen using a DNA strand exchange assay and was found to specifically inhibit human RAD51 (IC50=27.4 µM) but not its E. coli homolog (RecA)1. It sensitizes multiple myeloma cells to doxorubicin2 and potentiates breast cancer cell killing by therapeutic agents in mouse models3. B02 induces a heat-shock protein mediated cellular response that positively regulates the conversion of rcDNA to cccDNA via the authentic intracellular amplification pathway in human hepatoma cells.4