Piericidin A, CAS [[2738-64-9]]

Product Overview

• Article Name: Piericidin A, CAS [[2738-64-9]]
• Biozol Catalog Number: FBM-10-3467
• Supplier Catalog Number: 10-3467
• Alternative Catalog Number: FBM-10-3467-200UG, FBM-10-3467-1MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-(10-hydroxy-3,7,9,11-tetramethyl-2,4,7,11-tridecatetraenyl)-5,6-dimethoxy-3-methyl-4-pyridinol. Alternate Names: Piericidin A1, Shaoguanmycin B, SN 198E, AR-054

Product Description

Mitochondrial complex I inhibitor

Product Properties

• Molecular Weight: 415.57
• Purity: 94% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [2738-64-9]
• Formula: C25H37NO4

Application Notes

• Application Notes: A potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxidoreductase (complex I).1 Piericidin A is a ubiquinone analog which binds to the ubiquinone binding site of the enzyme.2 It is an extremely useful tool for exploring the role of complex I in mitochondrial function in both normal and pathophysiology.3-5 Prevents upregulation of GRP78 and induces cell death in glucose-deprived, etoposide-resistant HT-29 cells (IC50=7.7 nM).6