Chemical Name: 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate
Endocytosis inhibitor
Molecular Weight:
606.09
Purity:
98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[84-02-6]
Formula:
C20H24ClN3S 2C4H4O4
Application Notes:
Inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME.1 Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2 A clinically useful antipsychotic agent3 with antimigraine4 and antiemetic activity5.
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