Streptonigrin, CAS [[3930-19-6]]

Product Overview

• Article Name: Streptonigrin, CAS [[3930-19-6]]
• Biozol Catalog Number: FBM-10-3484
• Supplier Catalog Number: 10-3484
• Alternative Catalog Number: FBM-10-3484-1MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: Fermentation product from Streptomyces flocculus. Alternate Names: Bruneomycin, NSC-45383

Product Description

Induces heterochromatin formation

Product Properties

• Molecular Weight: 506.47
• Purity: >95% HPLC, NMR (Conforms)
• Form: Black solid
• CAS Number: [3930-19-6]
• Formula: C25H22N4O8

Application Notes

• Application Notes: Streptonigrin promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1alpha.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4