Chemical Name: 4-Methylbenzyl-N-bis[daunomycin], mesylate salt
Inhibits SP-1 activated transcription
Molecular Weight:
1349.38
Purity:
>98% by HPLC NMR (Conforms)
Form:
Red solid
Formula:
C62H64N2O20 2CH3SO3H
Application Notes:
A novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human ovarian cancer cells.3 Synergizes with epothilone at induction of apoptosis in human ovarian cancer cells.4 Abrogates HIV-1 replication via inhibition of Tat transactivation.5
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