Gramicidin A, CAS [[11029-61-1]]

Product Overview

• Article Name: Gramicidin A, CAS [[11029-61-1]]
• Biozol Catalog Number: FBM-10-3556
• Supplier Catalog Number: 10-3556
• Alternative Catalog Number: FBM-10-3556-1MG,FBM-10-3556-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: HCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu- Trp-D-Leu-Trp-NHCH2CH2OH. Alternate Names: Peptide fermentation product isolated from B brevis

Product Description

Channel-forming ionophore

Product Properties

• Molecular Weight: 1882.29
• Purity: >95% by HPLC, NMR (conforms)
• Form: White to off-white solid
• CAS Number: [11029-61-1]
• Formula: C99H140N20O17

Application Notes

• Application Notes: Gramicidin A (11029-61-1) is a hydrophilic non-ribosomal peptide ionophore that forms channels in membranes which are monovalent cation-permeable.1,2 Disruption of cellular ionic homeostasis is the basis for its antibiotic activity.3 It is also cytotoxic to a variety of cancer cell lines4 and tumor xenografts5. Gramicidin A was shown to stimulate melanoma differentiation-associated protein 5 (MDA5)-mediated IFN signaling by enhancing its oligomerization onto RNA and thus represents a new tool to manipulate MDA5 activity.6