IMR-1, CAS [[310456-65-6]]

Product Overview

• Article Name: IMR-1, CAS [[310456-65-6]]
• Biozol Catalog Number: FBM-10-3601
• Supplier Catalog Number: 10-3601
• Alternative Catalog Number: FBM-10-3601-5MG,FBM-10-3601-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Notch transcriptional activation inhibitor

Product Properties

• Molecular Weight: 353.41
• Purity: 98% by TLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [310456-65-6]
• Formula: C15H15NO5S2

Application Notes

• Application Notes: Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 M (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 M (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1