Chemical Name: N-(2,4-Dichlorobenzyl)-4-(methylsulfonamido)benzamide
TREK-1,2 activator
Molecular Weight:
373.25
Purity:
98% by TLC NMR (Conforms)
Form:
White solid
CAS Number:
[825658-06-8]
Formula:
C15H14Cl2N2O3S
Application Notes:
Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anaesthetics. ML335 is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 M1. It represents an important new pharmacological tool for studying the physiology of TREK channels.
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