NLRP3i, CAS [[16673-34-0]]

Product Overview

• Article Name: NLRP3i, CAS [[16673-34-0]]
• Biozol Catalog Number: FBM-10-3672
• Supplier Catalog Number: 10-3672
• Alternative Catalog Number: FBM-10-3672-20MG, FBM-10-3672-100MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide. Alternate Names: JC121

Product Description

NLRP3 inflammasome inhibitor

Product Properties

• Molecular Weight: 368.84
• Purity: 98% by TLC NMR (Conforms)
• Form: White solid
• CAS Number: [16673-34-0]
• Formula: C16H17ClN2O4S

Application Notes

• Application Notes: NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising in vivo protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1 and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2 Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2